Registration Dossier
Registration Dossier
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EC number: 639-864-4 | CAS number: 43133-95-5
Neurotoxicity
Administrative data
Description of key information
One read across key neurotoxicity study of commercial hexane was found (API, 1990; Klimisch=2).
Key value for chemical safety assessment
Effect on neurotoxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 31 680 mg/m³
Additional information
In a key study, the neurological effects of inhalation exposure to commercial hexane (53% n-hexane) in rats was examined (API, 1990; Klimisch score =2 since a read across approach was followed). Rats were exposed to nominal concentrations of 0, 900, 3000, or 9000 ppm for 6 hrs/day, 5 days/week, for 13 weeks. Rats were tested monthly throughout the exposure for hindlimb splay and grip strength. A functional observational battery was also performed regularly. Animals were also examined for clinical signs, body weight, and food consumption. Results showed no effects to behavior or evidence of toxicity. The NOAEC for sub-chronic neurological effects in rats was 9000 ppm (31680 mg/m3).
This study directly informs the DNEL.
Justification for classification or non-classification
This substance is not classified for neurotoxicity based on the negative results of a neurotoxicity study of commercial hexane containing 53% n-hexane.
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