Allyl 3-cyclohexylpropionate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Remarks:

Non-GLP study, slightly deviating from current testing guidelines

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

yes

Remarks:

necropsy of surivors and gross pathological examination not reported

Principles of method if other than guideline:

Groups of four animals were exposed topically to one dermal dose of test substance. Animals were observed during a period of 14 days.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Allyl 3-cyclohexylpropionate

EC Number:

220-292-5

EC Name:

Allyl 3-cyclohexylpropionate

Cas Number:

2705-87-5

Molecular formula:

C12H20O2

IUPAC Name:

prop-2-en-1-yl 3-cyclohexylpropanoate

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

Not reported

Administration / exposure

Type of coverage:

not specified

Vehicle:

not specified

Details on dermal exposure:

Not reported

Duration of exposure:

Not reported

Doses:

0.313, 1.25 and 5.0 g/kg body weight

No. of animals per sex per dose:

4

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: not reported

Statistics:

Not reported

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

1 600 mg/kg bw

Based on:

test mat.

95% CL:

430 - 2 770

Mortality:

In the low-dose group, no animal died during the observation period of 14 days. In the mid-dose group, one animal died on day one following dermal exposure. In the high-dose group, all animals died within the 14-day observation period; three animals were found dead on day 1 following dermal exposure, one animal died on observation day 4.

Clinical signs:

other: other: Ataxia was observed in one animal of the mid-dose group.

Gross pathology:

Not reported

Other findings:

The skin irritation potential of the substance was observed and moderate redness and oedema were observed in animals of all dose groups.

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category IV

Conclusions:

The substance was acutely toxic to rabbits in an acute dermal toxicity test with an LD50 value of 1600 mg/kg body weight. The substance is classified into Acute Toxicity Category IV according to CLP.

Executive summary:

The acute dermal toxicity of the test substance allyl cyclohexyl propionate was studied in a non-GLP test according to principles slightly deviating from those of current guidelines. Groups of four animals were exposed to single dermal doses of 0.313, 1.25 and 5.0 g/kg body weight. Animals were observed during a period of 14 days. No mortality was observed in the low-dose group, whereas one animal in the mid-dose group and 4 animals in the high-dose group died within the observation period. The LD50 value was 1.6 g/kg bw with a 95% confidence interval of 0.43 to 2.77 g/kg bw. Ataxia was observed in one animal dosed with 1.25 g/kg bw. Slight to moderate skin irritation was observed in animals of all dose groups.