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EC number: 266-005-7 | CAS number: 65996-72-7 The dust generated during the charging, operation, and tapping of a steelmaking furnace and from steel conditioning, including that which is recovered through the use of pollution abatement equipment. Composed primarily of iron oxides. May contain varying amounts of other metallic oxides and trace compounds.
The substance, Dust, steelmaking, was applied to laboratory animals (rat, mouse, and rabbit) during studies with different way of entry into organism (e.g. stomach, respiratory tract - nose, skin and eye).
Only mild systemic effects – piloerection only 3 hours after application in all animals were described after single oral application of the dose level 2000 mg/kg of the substance to rats. Observed changes faded away till 24 hours after application of the test substance.
Common clinical abnormalities (increased respiratory rate, hunched posture, piloerection and wet fur - till the 7th day after exposure) were noted after 4-hour nose exposure of the substance at the concentration of 5.15 mg/L.
After single application on skin of rabbit, no irritant or corrosive effects were observed. The substance is not irritant. No symptoms of systemic toxicity were observed in rabbits after application on skin.
Examination of eye after single application of substance to the conjunctival sac demonstrated, that Dust, steelmaking, is irritating for eye of rabbit; the changes observed were reversible (redness and chemosis of conjunctivae and lacrimation – these changes faded away till the 8th day of study). No corrosive effects were observed on eyes of rabbit and no clinical signs of systemic intoxication were detected.
The substance, Dust, steelmaking, elicited positive response after topical application to the mouse ear in LLNA; so the test substance may cause skin sensitisation by skin contact. No clinical signs of systemic intoxication were detected in study of sensitization.
The oral administration of the substance, Dust, steelmaking, to rats by gavage for a period of 28 consecutive days at dose levels 120, 300 and 750 mg/kg/day did not cause mortality.
The haematology examination showed an effect on total leucocyte count (statistically significant increase) in males of middle dose level with irreversible effect.
Only one statistically significant effect, which was manifested in results of biochemical examination was the increase of calcium and phosphorus ions concentrations in peripheral blood. Values of these ions were increased at the highest dose level in both sexes (in females statistically significant). This symptom had delayed character in males and irreversible effect in females. During biochemical examination also the changes of values of liver enzymes were detected - an insignificantly decreased activity of AST, ALT, ALP at the highest dose was recorded in both sexes. These changes have had irreversible character in all treated animals. Decreased value of creatinine with dose-dependent manner was recorded in females. All these changes together with increase of weight of liver (with dependence on dose level in males) can be indications of affection of liver metabolism but during histopathological investigation no changes of hepatocytes morphology were observed.
In Reproduction/Developmental Toxicity Screening Test the following dose levels: 100, 300 and 900 mg/kg/day were administered.
The application of the test substance did not cause the death of any female or male.
The test substance affected reproductive system of parental males. Histopathological examination of reproductive system of parental males showed vacuolation of cytoplasm of spermatogonia in testes in majority males of treated groups and lymphocyte infiltration in epididymides of all males. Also atrophy and degeneration of germ epithelium in testes and lymphocyte infiltration in interstitium of prostate gland was diagnosed at all groups. The test substance had probably injurious effect on sperm quality of treated males. Markedly increased impaired sperm motility was recorded at the lowest and middle dose levels.
At the highest dose level slightly increased sperm motility was recorded on the contrary. The effect of the test substance on sperm motility declined with the dose level. Increased percentage of affected sperms was recorded at all treated groups. Mainly damages of sperm head and sperm neck were diagnosed.
The number of pups, sex ratio, average weight of litter, average body weight of pups and postnatal development of pups were unaffected by the test substance treatment.
In Prenatal Developmental Toxicity Study the following dose levels: 1000, 400 and 160 mg/kg/day were administered.
The application of the test substance did not cause the death of pregnant females. No effect of the test substance on maternal animals was observed.
Test substance application did not induce external and/or visceral malformations of foetuses (permanent structural change that may adversely affect survival).
Delayed development of foetuses - delayed ossification of cranial, sternum skeleton and sacral vertebrae, was detected at all dose levels. These findings related with decreased individual body weights of some foetuses. The test substance treatment evoked occurrence of variations – wavy ribs in all treated groups, so it indicates teratogenic properties of the test substance (it did cause morphologic changes of skeleton) on early prenatal development of organism in uterus.
Evaluation of toxicokinetics of the substance Dust, steelmaking was performed. Evaluation of toxicokinetics of the substance is required according to the 8.8.1 of Annex VII to the Directive (EC) No. 1907/2006 (REACH).
Dust, steelmaking is the complex product of oxides and elements. The main components of the test substance are the following: Fe total 57.64 % (mainly as oxides) and CaO (8.89 %).
The evaluation of toxicokinetics of above mentioned substance was performed according to experimental data from the testing of Dust, steelmaking at CETA - VUOS.
The data used for the evaluation originated from three sources:
- Experimental data of toxicological tests (unpublished)
- Literature data obtained from internet
- Data from toxicological databases - free and commercial
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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