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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: It is not clear whether the individuals used were sensitized to the test substance itself, and therefore whether the negative result in this test is reliable.

Data source

Reference
Reference Type:
publication
Title:
Allergens in Rubber Products.
Author:
Kantoh H, Ishihara M, Itoh M, Hosono K
Year:
1992
Bibliographic source:
Skin Res., 27, 501-509

Materials and methods

Type of sensitisation studied:
skin
Study type:
other: patch test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-di-o-tolylguanidine
EC Number:
202-577-6
EC Name:
1,3-di-o-tolylguanidine
Cas Number:
97-39-2
Molecular formula:
C15H17N3
IUPAC Name:
1,3-di-o-tolylguanidine
Details on test material:
Other name: DOTG

Method

Type of population:
general
Subjects:
13 persons
Patch testing performed using individuals who exhibited contact dermatitis on contact with rubber.
Route of administration:
dermal
Details on study design:
vehicle: petrolatum

Results and discussion

Results of examinations:
0/13 subjects showed a reaction to the test substance.

Applicant's summary and conclusion

Conclusions:
DOTG is not a skin sensitizer according to this patch test study.