Registration Dossier
Registration Dossier
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EC number: 202-577-6 | CAS number: 97-39-2
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: It is not clear whether the individuals used were sensitized to the test substance itself, and therefore whether the negative result in this test is reliable.
Data source
Reference
- Reference Type:
- publication
- Title:
- Allergens in Rubber Products.
- Author:
- Kantoh H, Ishihara M, Itoh M, Hosono K
- Year:
- 1 992
- Bibliographic source:
- Skin Res., 27, 501-509
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- other: patch test
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,3-di-o-tolylguanidine
- EC Number:
- 202-577-6
- EC Name:
- 1,3-di-o-tolylguanidine
- Cas Number:
- 97-39-2
- Molecular formula:
- C15H17N3
- IUPAC Name:
- 1,3-di-o-tolylguanidine
- Details on test material:
- Other name: DOTG
Constituent 1
Method
- Type of population:
- general
- Subjects:
- 13 persons
Patch testing performed using individuals who exhibited contact dermatitis on contact with rubber. - Route of administration:
- dermal
- Details on study design:
- vehicle: petrolatum
Results and discussion
- Results of examinations:
- 0/13 subjects showed a reaction to the test substance.
Applicant's summary and conclusion
- Conclusions:
- DOTG is not a skin sensitizer according to this patch test study.
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