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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP screening study
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1998
Report date:
1998

Materials and methods

Principles of method if other than guideline:
3 single oral doses of test material were administered to three groups of rats.
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4-dichloro-5-isopropoxyaniline
EC Number:
255-258-9
EC Name:
2,4-dichloro-5-isopropoxyaniline
Cas Number:
41200-96-8
Molecular formula:
C9H11Cl2NO
IUPAC Name:
2,4-dichloro-5-(propan-2-yloxy)aniline
Details on test material:
- Name of test material (as cited in study report): 2,4-dichloro 5-isopropoxy aniline (DIA)
- Storage condition of test material: stored in the dark at room temperature in air-tight containers

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: unspecified
Doses:
25; 200 and 2000 mg/kg bw

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Under the test conditions, 2,4-Dichloro-5-isopropoxyaniline is not classified for acute oral toxicity in the rat according to the criteria of the Regulation (EC) 1272/2008 and the Directive 67/548/EEC as the LD 50 is higher than 2000 mg/kg bw.
Executive summary:

In an acute oral toxicity screening study, performed in compliance with the GLP, three groups of rats were given a single oral dose of undiluted 2,4-Dichloro-5-isopropoxyaniline (named as 2,4-dichloro 5-isopropoxy aniline (DIA) in the study report) at doses of 25; 200 or 2000 mg/kg bw.

 

Oral LD50rat > 2000 mg/kg bw

Under the test conditions, 2,4-Dichloro-5-isopropoxyaniline is not classified for acute oral toxicity in the rat according to the criteria of the Regulation (EC) 1272/2008 and the Directive 67/548/EEC as the LD 50 is higher than 2000 mg/kg bw.