2,4-dichloro-5-isopropoxyaniline

Genetic toxicity: in vitro

Administrative data

Endpoint:

in vitro gene mutation study in bacteria

Remarks:

Type of genotoxicity: gene mutation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: GLP screening study

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1998

Report date:

1998

Materials and methods

Principles of method if other than guideline:

Ames tests in two bacterial strains (S. typhimurium TA98 and TA100).

GLP compliance:

yes

Type of assay:

bacterial reverse mutation assay

Test material

Test material information

Constituent 1

Reference substance name:

2,4-dichloro-5-isopropoxyaniline

EC Number:

255-258-9

EC Name:

2,4-dichloro-5-isopropoxyaniline

Cas Number:

41200-96-8

Molecular formula:

C9H11Cl2NO

IUPAC Name:

2,4-dichloro-5-(propan-2-yloxy)aniline

Details on test material:

- Name of test material (as cited in study report): 2,4-dichloro 5-isopropoxy aniline (DIA)
- Storage condition of test material: stored in the dark at room temperature in air-tight containers

Method

Species / strain

Species / strain / cell type:

other: Salmonella typhimurium TA98 and TA100

Metabolic activation:

with and without

Results and discussion

Any other information on results incl. tables

No indication of the test results provided

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information):
positive with metabolic activation
negative without metabolic activation

Under the test conditions, 2,4-Dichloro-5-isopropoxyaniline induced a strong mutagenic activity in the bacterial strains S. typhimurium TA98 and TA100 with metabolic activation only.

Executive summary:

In a reverse gene mutation assay in bacteria performed in compliance with the GLP, Salmonella typhimurium TA98 and TA100 were exposed to 2,4-Dichloro-5-isopropoxyaniline (named as 2,4-dichloro 5-isopropoxy aniline (DIA) in the report). A strong mutagenic activity in both strains was observed with metabolic activation only.