Registration Dossier
Registration Dossier
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EC number: 924-055-3 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Exposure to rock wool fibers produced no interstitial fibrosis or neoplastic lesions at any time point.
Rock wool (stone wool) produced no fibrotic response or neoplasms.
These studies demonstrate that the inhalation of high levels of rock (stone) and slag wools, while causing nonspecific inflammatory lesions (rock and slag wool) and fibrosis with high lung burden of long fibers (rock wool only) in the lungs of exposed rats, showed no evidence of carcinogenic activity. These results suggest that respirable fractions of these MMVFs should not pose a significant health risk to humans at the relatively low airborne levels found in the workplace.
So are assessed to be not mutagenic.
Short description of key information:
Using data from long term inhalation studies, the MMVF are deemed to be not mutagenic in bacteria or in mammalian cells.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Using data from long term inhalation studies, the MMVF are deemed to be not mutagenic in bacteria or in mammalian cells.
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