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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Conducted according to techniques specified in national regulations.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report date:
1971

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Regulations for the Enforcement of the Federal Hazardous Substances Act (Revised, Federal Register, Sept 17, 1964)
Deviations:
no
Principles of method if other than guideline:
Skin irritation was assessed as a part of the dermal toxicity study referenced above in 7.2.3
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-[(morpholinothio)thioxomethyl]morpholine
EC Number:
237-335-9
EC Name:
4-[(morpholinothio)thioxomethyl]morpholine
Cas Number:
13752-51-7
Molecular formula:
C9H16N2O2S2
IUPAC Name:
morpholin-4-yl morpholine-4-carbodithioate
Details on test material:
- Name of test material (as cited in study report): 3030x18
- Physical state: sparkly white powder
- Other: Received at testing laboratory on Sept 3, 1971

Test animals

Species:
rabbit

Test system

Type of coverage:
semiocclusive
Preparation of test site:
other: abraded and unabraded
Vehicle:
physiological saline
Controls:
no
Amount / concentration applied:
1.00, 2.15, 4.64 and 10.0 gm/Kg of body weight.
Duration of treatment / exposure:
24 hours
Observation period:
14 days
Number of animals:
4 groups of 4 animals

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: erythema visual assessment
Time point:
other: end of exposure period
Reversibility:
fully reversible within: 2 - 5 days
Remarks on result:
other: Score not specified
Irritation parameter:
other: mild desquamation
Time point:
other: day 1-2 post exposure
Reversibility:
not fully reversible within: 14 days
Remarks on result:
other: no score was given
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Remarks on result:
other: 24/48/72 hours not specified
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Remarks on result:
other: 24/48/72 hours not specified
Irritant / corrosive response data:
Mild, diffuse erythema was the only irritative effect noted in animals upon completion of the exposure period. This subsided in 2-5 days. Mild desquamation was noted within 1 to 6 days and generally persisted through termination of the study.

Any other information on results incl. tables

Mild, diffuse erythema was the only irritative effect noted in animals upon completion of the exposure period. This subsided in 2-5 days. Mild desquamation was noted within 1 to 6 days and generally persisted through termination of the study.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Cure-rite 18 did not cause local irritative effects, other than mild, diffuse erythema and mild desquamation, up to 10,000 mg/kg.