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Registration Dossier
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EC number: 215-293-2 | CAS number: 1319-77-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: sufficient information to evaluate the substance
Data source
Reference
- Reference Type:
- publication
- Title:
- Bio-Fax data sheet: o-cresol
- Author:
- Industrial Bio-Test Laboratories Inc.
- Year:
- 1 969
- Bibliographic source:
- Data sheet no 4-5/69, Industrial Bio-Test Laboratories Inc. Northbrook, Ill, USA
Materials and methods
- Principles of method if other than guideline:
- Method: other: application of 0.1 ml of the undiluted substance into the eye of each of 6 rabbits reading 24hrs, 48 hrs and 72 hours : cornea, iris,
conjunctivae - GLP compliance:
- no
Test material
- Reference substance name:
- o-cresol
- EC Number:
- 202-423-8
- EC Name:
- o-cresol
- Cas Number:
- 95-48-7
- Molecular formula:
- C7H8O
- IUPAC Name:
- o-cresol
- Details on test material:
- IUCLID4 Test substance: other TS: o-cresol, no data on purity, MP 30 °C
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no further information
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the second eye served as control
- Amount / concentration applied:
- undiluted
Amount applied: 0.1 ml - Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- up to 72 hours
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- Comment: no data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: cornea score, iris score, conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 hour reading
- Score:
- ca. 91.3
- Max. score:
- 110
- Irritation parameter:
- other: cornea score, iris score, conjunctivae score
- Basis:
- mean
- Time point:
- other: 48 hour reading
- Score:
- ca. 86.3
- Max. score:
- 110
- Irritation parameter:
- other: cornea score, iris score, conjunctivae score
- Basis:
- mean
- Time point:
- other: 72 hour reading
- Score:
- ca. 82.7
- Max. score:
- 110
- Reversibility:
- not specified
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: after 72 hour reading
- Score:
- ca. 91.3
- Max. score:
- 110
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- no further data
- Other effects:
- none reported
Any other information on results incl. tables
RS-Freetext:
Total irritation score: 91.3/110
Applicant's summary and conclusion
- Executive summary:
Application of 0.1 ml undiluted testsubstance into the eyes of rabbits and observation for up to 72 hours resulted into a mean score of 97 of max 110. Reversibility is not reported (Industrial Biotest Laboratories 1969).
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