Registration Dossier
Registration Dossier
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EC number: 238-969-9 | CAS number: 14901-07-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one(b-Ionone) in aqueous suspension with gum Arabic was administered by stomach tube to a male albino rabbit weighing about 3.0 kg at a dose of 1 g/kg/day for seven days.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The total administered dose was 23 g. Urine was collected everyday during the dosing period and for 4 days after the last dose. Urine samples were extracted and analyzed forb-ionone and its metabolites. The results showed that there were five free metabolites in urine. These included 3-oxo-b-ionone, 3-oxo-b-ionol, dihydro-3-oxob-ionol, 3-hydroxy-b-ionol and unchangedb-ionone. Additionally, two glucuronides ofb-ionol were detected.Glucuronides were hydrolyzed withb-glucuronidase and were identified as the glucuronides of 3-oxo-b-ionol and dihydro-3-oxo-b-ionol
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