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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Estimation of the acid base properties based on the chemical structure.
Analytical Development Physical Chemistry, Schering AG Berlin. Study report No. A11913 (ADP 2003_018), dated 2003-01-10.
Result: Estron-Methylether can be considered as a neutral molecule in the pH range 2 to 10, which is of relevance for biological systems.

Key value for chemical safety assessment

Additional information

Estron-Methylether does not contain any functional group which can be protonated or deprotonated significantly in aqueous solution. The pKa calculation with the computer program ACD/pKa DB gave no result.

Therefore, Estron-Methylether is to be considered as a neutral molecule in the pH range 2 ¿ 10, which is of relevance for aqueous biological systems.