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Description of key information

Estimation of the acid base properties based on the chemical structure.
Analytical Development Physical Chemistry, Schering AG Berlin. Study report No. A11913 (ADP 2003_018), dated 2003-01-10.
Result: Estron-Methylether can be considered as a neutral molecule in the pH range 2 to 10, which is of relevance for biological systems.

Key value for chemical safety assessment

Additional information

Estron-Methylether does not contain any functional group which can be protonated or deprotonated significantly in aqueous solution. The pKa calculation with the computer program ACD/pKa DB gave no result.

Therefore, Estron-Methylether is to be considered as a neutral molecule in the pH range 2 ¿ 10, which is of relevance for aqueous biological systems.