N'-(3-aminopropyl)-N,N-dimethylpropane-1,3-diamine

Developmental toxicity / teratogenicity

Administrative data

Endpoint:

developmental toxicity

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP-conform OECD Guideline study

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2012

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3,3'-iminodi(propylamine)

EC Number:

200-261-2

EC Name:

3,3'-iminodi(propylamine)

Cas Number:

56-18-8

IUPAC Name:

N-(3-aminopropyl)propane-1,3-diamine

Constituent 2

Reference substance name:

Dipropylenetriamine

IUPAC Name:

Dipropylenetriamine

Test animals

Species:

rat

Strain:

Wistar

Administration / exposure

Route of administration:

oral: gavage

Duration of treatment / exposure:

Males were exposed for 30 days (prior to mating, during mating, and up to termination) and females 49 days (prior to mating, during mating, during post-coitum, and at least 4 days of lactation).

Frequency of treatment:

Daily

Doses / concentrations

Remarks:

Doses / Concentrations:
5, 15 and 50 mg/kg bw/d
Basis:
actual ingested

Control animals:

yes, concurrent vehicle

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

1

Dose descriptor:

NOAEL

Effect level:

15 mg/kg bw/day (actual dose received)

Based on:

test mat.

Basis for effect level:

other: maternal toxicity

2

Dose descriptor:

NOAEL

Effect level:

15 mg/kg bw/day (actual dose received)

Based on:

test mat.

Basis for effect level:

other: developmental toxicity

Results (fetuses)

Fetal abnormalities

Abnormalities:

not specified

Overall developmental toxicity

Developmental effects observed:

not specified