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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Reference from collection of data in review article.

Data source

Reference
Reference Type:
review article or handbook
Title:
Aniline—A ‘Historical’ Contact Allergen? Current Data from the IVDK and Review of the Literature
Author:
Uter W., Stropp G., Schnuch A. and Lessmann H.
Year:
2007
Bibliographic source:
Ann. Occup. Hyg., Vol. 51, No. 2, pp. 219–226

Materials and methods

Type of sensitisation studied:
skin
Study type:
other: Study on patients with dermatitis and already sensitized to p-phenylenediamine.
Test guideline
Qualifier:
no guideline required
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
N-methylaniline
EC Number:
202-870-9
EC Name:
N-methylaniline
Cas Number:
100-61-8
Molecular formula:
C7H9N
IUPAC Name:
N-methylaniline

Method

Type of population:
other: 160 patients with contact allergy to p-phenylenediamine
Controls:
Not included, reaction to test substance was compared to reaction to other anilines.
Route of administration:
dermal

Results and discussion

Results of examinations:
None of 40 patients positive when tested with 5% test substance and N,N-dimethylaniline; 37/58 patients positive when tested with 2% p-toluidine.

Applicant's summary and conclusion

Conclusions:
In contrast to 4-methylaniline, test substance did not induce an allergic reaction in patients hypersensitive to p-phenylenediamine.