1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18(even numbered) acyl) derivs., hydroxides, inner salts

Flash point

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

flash point of flammable liquids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 16 May 2012 to 06 December 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The study was conducted according to internationally recognised guidelines, and under GLP. No deviation affected the quality of the study. The study was performed on the commercial product (aqueous solution) as the test item is manufactured and used in a liquid form.

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

EU Method A.9 (Flash-Point)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

2012-12-15

Type of method:

equilibrium method closed cup

Key result

Remarks on result:

other: no flash point up to 120°C (at this temperature the test item started to boil)

Preliminary results:

Atmospheric pressure                    About 98.4 kPa

Relative humidity                 About 49% of saturated air

Temperature(°C)			Flash observation
Setaflash display (OT)	Setaflash corrected (CT)	Corrected to Patm (C)
69.7	69.5	70.0	No
79.7	79.5	80.0	No
89.8	89.5	90.0	No
99.8	99.5	100.0	No
109.9	109.5	110.0	No
119.9	119.5	120.0	No

No flash point was observed up to 120.0 °C(corrected values).

At 120.0 °C, the test item boiled and overflowed of the dish just before the presentation of the flame. Then the test was stopped.

Results of the main test:

Based on the results of the preliminary test, no main test was performed.

Interpretation of results:

GHS criteria not met

Conclusions:

No flash point was observed up to 120.0 °C (corrected value).

Executive summary:

The flash point of the test item (= substance EC 939-455-3 in aqueous commercial product) was investigated in a GLP-compliant study performed in accordance with EU Method A.9 (Flash-Point) using a closed-cup equilibrium method. No flash point was observed up to 120.0 °C, temperature at which the test item started to boil.

The study was performed on a commercial product (aqueous solution) as the substance EC 939-455-3 is manufactured and used in a liquid form.

Reference 2

Endpoint:

flash point of flammable liquids

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
C8-C18 AAPHS and C12-18 AAPHS have the same functional groups, and general composition. The main variable resides in the alkyl chain distribution.

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Source chemical = C8-18 cocamidopropyl hydroxysultaine (EC 939-455-3).
Target chemical = C12-18 cocamidopropyl hydroxysultaine (EC 939-457-4).

3. ANALOGUE APPROACH JUSTIFICATION
The alkyl C-chain distribution of the source chemical significantly overlaps with the one of the target chemical, the C12-alkyl derivative being the major constituent in both chemicals. The structural differences in side C-chains is not expected to lead to significant differences on phys-chem properties.

4. DATA MATRIX
See "Documentation and scientific justification of the read-across approach" in section 13.2.

Reason / purpose for cross-reference:

read-across source

Key result

Remarks on result:

other: no flash point up to 120°C (at this temperature the test item started to boil)

Remarks:

read-across from EC 939-455-3 in aqueous solution

Conclusions:

By analogy with the source substance EC 939-455-3 in aqueous solution, no flash point was reported up to 120°C for the target substance 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-457-4) in aqueous solution, at a similar concentration range.

The source and target substances are both manufactured and used in a liquid form (aqueous solutions at a similar contentration range). The security physico-chemical parameters were therefore assessed from tests performed on aqueous solutions.

Description of key information

The substance EC 939-457-4 is manufactured and used in a liquid form (aqueous solutions). The security physico-chemical parameters were therefore assessed from tests performed on aqueous solutions.

As the flash point of the substance EC 939-457-4 in aqueous solution have not been determined experimentally, a read-across approach was followed to fill in the endpoint. The flash point of a structural analogue substance (= source substance EC 939-455-3) in aqueous solution was investigated in a GLP-compliant study (Colombies, 2013) performed in accordance with EU Method A.9 (Flash-Point) using a closed-cup equilibrium method. No flash point was observed up to 120.0 °C, temperature at which the aqueous solution started to boil. By analogy, no flash point was reported up to 120°C for the target substance 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-457-4) in aqueous solution, at a similar concentration range.

The alkyl C-chain distribution of the source substance EC 939-455-3 significantly overlaps with the one of the target substance EC 939-457-7, the C12-alkyl derivative being the major constituent in both chemicals. The structural differences in side C-chains is not expected to lead to significant differences on phys-chem properties.

Additional information

The flash point of the structural analogue substance (= source substance EC 939-455-3) in aqueous solution was investigated in a GLP-compliant study (Colombies, 2013) performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and was selected as key study for the endpoint of the target substance EC 939-457-4 in aqueous solution.