Registration Dossier
Registration Dossier
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EC number: 203-685-6 | CAS number: 109-59-1
Endpoint summary
Administrative data
Description of key information
Additional information
Using the AOPWIN QSAR model, the photochemical degradation rate of 2 -(2 -ethoxyethoxy)ethanol in the atmosphere is 23.2 E-12 cm3/molecule-sec, with a resultatnt predicted half live of 5.5 Hrs.
In an approved guideline OECD301F study conducted to GLP, isopropyl glycol ether was only 23% biodegraded at 28 days in a predominatly unadapted domestic sewage sludge and therefore failed to meet the criteria for ready biodegradability. The result may have been better in an adapted industrial sludge rather than an unadapted domestic sludge. In an OECD301C guideline and GLP study, a test of 2-isopropoxyethanol in activated sludge resulted in 8% degradation after 28 days cultivation period. Part of 2 -isopropoxyethanol was converted to 2 -(1 -methylethoxy)ethanoic acid during the cultivation period. Biodegradation testing with the isomer of isopropoxyethanol (n-propoxyethanol) conducted under a modified guideline method showed the latter to be readily biodegradable at 20 days under aerobic conditions with non-acclimated sewage microorganisms. The US EPA Biowin v. 4.10 QSAR model predicts that both n- and isopropoxyethanol will be readily biodegradable. The results in 6 of the 7 models within the QSAR gave identical predictions and in only one did it predict that n-propoxyethanol would be readily biodegradable but isopropoxyethanol would not be. The data suggests that isopropoxyethanol is less readily degradable than n-propoxyethanol and cannot, on present information, be considered readily biodegradable.
In a study that followed the principles of a guideline activated sludge simulation test, a reactor system set up to model the WWTP used on the site of a manufacturer was dosed with increasingly levels of isopropyl glycol ether. The sludge reactor influent used was the same as used for the full scale plant as was the activated sludge. When running with an influent stream containing up to 150ul/litre of isopropyl glycol ether, the reactor ran with a degradation efficiency of 97%. There was evidence of adaptation occuring and also complete removal of all biologically available oxygen from the influent stream.
The overall available data suggests however that this substance can be considered inherently biodegradable for the purposes of risk characterisation.
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