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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Description of key information

NOEC (72hr) P subcaptitata NOEC>1000mg/l (study 1).
NOEC (72hr) P subcaptitata EC50=6418mg/l (study 2).
QSAR prediction (96hr): EC50=440mg/l, ChV=84mg/l.

Key value for chemical safety assessment

EC50 for freshwater algae:
6 418 mg/L
EC10 or NOEC for freshwater algae:
1 000 mg/L

Additional information

A guideline and GLP 72 hr study in Pseudokirchneriella subcapitata established that the NOEC was greater than the maximum tested concentration of 1000mg/l. In a set of experiments designed to generate a dataset for the development of a QSAR model, the toxicity of isopropyl glycol ether to the algae P subcapitata was assessed using a modified guideline protocol modified to increase throughput and to cope with sealed systems to allow testing of volatile substances. The measured EC50 was 6418mg/L. This latter definitive figure is used for the EC50 whilst the measured value for the EC10 from the second study is used as the NOEC. A QSAR predicts that the NOEC is lower at 84mg/l and the EC50 440mg/l. The QSAR seems to significantly over-estimate toxicity to algae.