5-amino-2,4,6-triiodo-1,3-benzenedicarbonyldichloride

Endpoint summary

Description of key information

Short term toxicity to fish: LC100 (96h) > 20mg/l

Short term to aquatic invertebrates: EC100 (48h) > 20mg/l

Toxcity to aquatic algae and cyanobacteria: EC50 (72h) growth rate > 1.9 mg/l. NOEC growth rate = 1.1 mg/l.

Toxicity to microrganisms: IC50 (0.5h) > 100 mg/l

Additional information

Short-term toxicity to fish

The acute toxicity of the test item on Cyprinus carpio fish was evaluated according to EU Method C1.

The LC100 value at 96 hours was greater than 20mg/l.

 

Short-term toxicity to aquatic invertebrates

The aquatic toxicity of the test item to aquatic invertebrates was evaluated in a limit test according to EU Method C2.

The EC100 was found to be greater than 20 mg/l.

 

Toxicity to aquatic algae and cyanobacteria

The toxicity of the test item to green alga Pseudokirchneriella subcapitata was determined according to EU Method C3.

The EC50 value for inhibition of growth rate and biomass after 72 hours was > 1.9 mg/l.

 

Toxicity to microorganisms

The respiration inhibitory effects of the test item to the microorganisms was investigated according to EEC directive 67/548 amended November 18, 1987 (87/302), part C: Methods for the determination of ecotoxicity, publication N° L133, "Biodegradation.

Under the test conditions the substance was not toxic to waste-water bacteria.

 

Justification for classification

Within the CLP Regulation (EC 1272/2008), classification for acute and chronic aquatic toxicity is based on data on fish, crustacea and algae or other aquatic plants.

Acute (short-term) aquatic hazard:

In particular, classification for acute toxicity applies when LC50 (96h) on fish, and/or, EC50 (48h) on crustacea and/or ErC50 (72 or 96h) on algae is ≤ 1 mg/l.

Long-term aquatic hazard:

Substances for which adequate chronic toxicity data are not available and the substance is not readily biodegradable and/or the experimentally determined BCF≥500 (or, if absent, the log Kow≥4).

In particular, classification in:

- category chronic 1 applies for acute toxicity data ≤ 1 mg/l;

- category chronic 2 applies for acute toxicity data between 1 and 10 mg/l;

- category chronic 3 applies for acute toxicity data between 10 and 100 mg/l.

 

Based on the available data the test substance has toxic effects on fish, crustacea, algae and cyanobacteria trophic levels. However, the algae results to be the mosts sensitive species with an effect level (EC50) > 1.9 mg/l. For this reason the proposed classification for the test substance is  Aquatic Chronic Category 2, according to the CLP Regulation (EC) 1272/2008.