Registration Dossier
Registration Dossier
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EC number: 417-220-1 | CAS number: 37441-29-5 ATIPACL
Endpoint summary
Administrative data
Description of key information
Skin sensitiser
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Based on the results of a Magnusson & Klingman Maximisation Test, the test substance showed an extreme grade of skin-sensitising (contact allergenic) potential in albino guinea pigs. 100% of the animals were sensitised by the test substance under the experimental conditions employed.
Therefore, according to EU criteria, the substance is sensitising for skin.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
According to the CLP Regulation (EC )1272/2008, skin sensitiser means a sustance that will lead to an allergic response following skin contact. Substances shall be classified as skin sensitisers (Category 1):
a) if there is evidence in humans that the substance can lead to sensitisation by skin contact in a substantial number of persons; or
b) if there are positive results from an appropriate animal test (e.g. Local lymph node assay, Guinea pig maximisation test, Buehler assay)
Based on the available data, a classification as Skin Sens. 1 (H317) according to CLP criteria set out in Regulation 1272/2008 is proposed for the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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