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Registration Dossier
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EC number: 204-885-6 | CAS number: 128-42-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- DPIM : DVF600
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials) : Gigiena i Sanitariya. 45(3) (1980), 73.
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : WJ6625000
- Author:
- RTECS Database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances): Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(3),73,1980
- Reference Type:
- other: Authoritative data base
- Title:
- GCID : 56738
- Author:
- ACTOR Database
- Year:
- 2 011
- Bibliographic source:
- ACToR (Aggregated Computational Toxicology Resource) : Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(3), Pg. 73, 1980.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from SAX, RTECS and ACTOR
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 4,4'-dinitrostilbene-2,2'-disulphonic acid
- EC Number:
- 204-885-6
- EC Name:
- 4,4'-dinitrostilbene-2,2'-disulphonic acid
- Cas Number:
- 128-42-7
- Molecular formula:
- C14H10N2O10S2
- IUPAC Name:
- 4,4'-dinitrostilbene-2,2'-disulphonic acid
- Details on test material:
- - Name of test material (as cited in study report): 4,4'-dinitrostilbene-2,2'-disulphonic acid
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 71 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Lethal dose, 50 percent kill
- Other findings:
- Toxic Effects : Liver - liver function tests impaired Kidney/Ureter/Bladder - renal function tests depressed
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of 4,4'-dinitrostilbene-2,2'-disulphonic acid in Rodent guinea pig on the basis of mortality effect was found to be 71000 mg/kg of body weight. This value indicates that 4,4'-dinitrostilbene-2,2'-disulphonic acid does not exhibits acute toxicity by the oral route.
- Executive summary:
The acute oral median lethal dose (LD50) of 4,4'-dinitrostilbene-2,2'-disulphonic acid in Rodent guinea pig on the basis of mortality effect was found to be 71000 mg/kg of body weight. This value indicates that 4,4'-dinitrostilbene-2,2'-disulphonic acid does not exhibits acute toxicity by the oral route.
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