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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
DPIM : DVF600
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials) : Gigiena i Sanitariya. 45(3) (1980), 73.
Reference Type:
review article or handbook
Title:
RTECS Number : WJ6625000
Author:
RTECS Database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances): Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(3),73,1980
Reference Type:
other: Authoritative data base
Title:
GCID : 56738
Author:
ACTOR Database
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource) : Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(3), Pg. 73, 1980.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from SAX, RTECS and ACTOR
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
4,4'-dinitrostilbene-2,2'-disulphonic acid
EC Number:
204-885-6
EC Name:
4,4'-dinitrostilbene-2,2'-disulphonic acid
Cas Number:
128-42-7
Molecular formula:
C14H10N2O10S2
IUPAC Name:
4,4'-dinitrostilbene-2,2'-disulphonic acid
Details on test material:
- Name of test material (as cited in study report): 4,4'-dinitrostilbene-2,2'-disulphonic acid
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
71 000 mg/kg bw
Based on:
test mat.
Mortality:
Lethal dose, 50 percent kill
Other findings:
Toxic Effects : Liver - liver function tests impaired Kidney/Ureter/Bladder - renal function tests depressed

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral median lethal dose (LD50) of 4,4'-dinitrostilbene-2,2'-disulphonic acid in Rodent guinea pig on the basis of mortality effect was found to be 71000 mg/kg of body weight. This value indicates that 4,4'-dinitrostilbene-2,2'-disulphonic acid does not exhibits acute toxicity by the oral route.
Executive summary:

The acute oral median lethal dose (LD50) of 4,4'-dinitrostilbene-2,2'-disulphonic acid in Rodent guinea pig on the basis of mortality effect was found to be 71000 mg/kg of body weight. This value indicates that 4,4'-dinitrostilbene-2,2'-disulphonic acid does not exhibits acute toxicity by the oral route.

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