Registration Dossier
Registration Dossier
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EC number: 204-885-6 | CAS number: 128-42-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- DPIM : DVF600
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials) : Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia.: , 1972, 194.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from handbook of 'SAX (Sax's Handbook of Dangerous Industrial Materials)'
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4,4'-dinitrostilbene-2,2'-disulphonic acid
- EC Number:
- 204-885-6
- EC Name:
- 4,4'-dinitrostilbene-2,2'-disulphonic acid
- Cas Number:
- 128-42-7
- Molecular formula:
- C14H10N2O10S2
- IUPAC Name:
- 4,4'-dinitrostilbene-2,2'-disulphonic acid
- Details on test material:
- - Name of test material (as cited in study report): 4,4'-dinitrostilbene-2,2'-disulphonic acid
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- 24H
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hr
- Reversibility:
- not specified
- Remarks on result:
- other: Dose : 500 mg/24H , Severe Irritation
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Administration of 4,4'-dinitrostilbene-2,2'-disulphonic acid to rodent-rabbit at a dose concentration of 500mg for 24 hrs resulted in a severe eye irritation.
- Executive summary:
Administration of 4,4'-dinitrostilbene-2,2'-disulphonic acid to rodent-rabbit at a dose concentration of 500mg for 24 hrs resulted in a severe eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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