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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro DNA damage and/or repair study
Remarks:
Type of genotoxicity: DNA damage and/or repair
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
Danish QSAR study for CAS No.: 128-42-7
Author:
Danish EPA Model
Year:
2012
Bibliographic source:
QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database:-DK-EPA

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Modelling Database
Principles of method if other than guideline:
Data is from DEPA
GLP compliance:
no
Type of assay:
DNA damage and repair assay, unscheduled DNA synthesis in mammalian cells in vitro

Test material

Constituent 1
Chemical structure
Reference substance name:
4,4'-dinitrostilbene-2,2'-disulphonic acid
EC Number:
204-885-6
EC Name:
4,4'-dinitrostilbene-2,2'-disulphonic acid
Cas Number:
128-42-7
Molecular formula:
C14H10N2O10S2
IUPAC Name:
4,4'-dinitrostilbene-2,2'-disulphonic acid
Details on test material:
- Name of test material (as cited in study report): 4,4'-dinitrostilbene-2,2'-disulphonic acid
- Substance type: Organic
- Physical state: Solid

Method

Species / strain
Species / strain / cell type:
hepatocytes: rat hepatocytes
Additional strain / cell type characteristics:
not specified
Metabolic activation:
not specified
Metabolic activation system:
no data

Results and discussion

Test results
Species / strain:
hepatocytes: rat hepatocytes
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

4,4'-dinitrostilbene-2,2'-disulphonic acid gives negative result for Unscheduled DNA synthesis in rat hepatocyte by using Multicase model.
Executive summary:

4,4'-dinitrostilbene-2,2'-disulphonic acid gives negative result for Unscheduled DNA synthesis in rat hepatocyte by using Multicase model.

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