Registration Dossier
Registration Dossier
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EC number: 204-885-6 | CAS number: 128-42-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro DNA damage and/or repair study
- Remarks:
- Type of genotoxicity: DNA damage and/or repair
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.: 128-42-7
- Author:
- Danish EPA Model
- Year:
- 2 012
- Bibliographic source:
- QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database:-DK-EPA
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Modelling Database
- Principles of method if other than guideline:
- Data is from DEPA
- GLP compliance:
- no
- Type of assay:
- DNA damage and repair assay, unscheduled DNA synthesis in mammalian cells in vitro
Test material
- Reference substance name:
- 4,4'-dinitrostilbene-2,2'-disulphonic acid
- EC Number:
- 204-885-6
- EC Name:
- 4,4'-dinitrostilbene-2,2'-disulphonic acid
- Cas Number:
- 128-42-7
- Molecular formula:
- C14H10N2O10S2
- IUPAC Name:
- 4,4'-dinitrostilbene-2,2'-disulphonic acid
- Details on test material:
- - Name of test material (as cited in study report): 4,4'-dinitrostilbene-2,2'-disulphonic acid
- Substance type: Organic
- Physical state: Solid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- hepatocytes: rat hepatocytes
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- not specified
- Metabolic activation system:
- no data
Results and discussion
Test results
- Species / strain:
- hepatocytes: rat hepatocytes
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
4,4'-dinitrostilbene-2,2'-disulphonic acid gives negative result for Unscheduled DNA synthesis in rat hepatocyte by using Multicase model. - Executive summary:
4,4'-dinitrostilbene-2,2'-disulphonic acid gives negative result for Unscheduled DNA synthesis in rat hepatocyte by using Multicase model.
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