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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets national standard methods with acceptable restrictions.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1982

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4-dichloro-5-sulphamoylbenzoic acid
EC Number:
220-358-3
EC Name:
2,4-dichloro-5-sulphamoylbenzoic acid
Cas Number:
2736-23-4
Molecular formula:
C7H5Cl2NO4S
IUPAC Name:
2,4-dichloro-5-sulfamoylbenzoic acid
Test material form:
solid - liquid: suspension
Details on test material:
M12325 was supplied by Hodogaya ChemicalCo., Ltd. (Tokyo, Japan).
State: water-soluble white powder
Melting point of 232 to 233.5°C.

Test animals

Species:
mouse
Strain:
other: ddY
Sex:
male
Details on test animals or test system and environmental conditions:
Male weight at study initiation: 25 to 30 g

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Remarks:
Distilled water
Doses:
3 g/kg
No. of animals per sex per dose:
10 male
Control animals:
yes
Details on study design:
Mortality and clinical signs of abnormalities were observed for 7 days.
Statistics:
The significance of differences in survival rate was evaluated by the Fisher exact test.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 3 000 mg/kg bw
Mortality:
No mortality was observed.
Clinical signs:
No clinical signs were observed.

Applicant's summary and conclusion

Conclusions:
The substance was well tolerated in single intraperitoneal doses up to 3 g/kg in mice.

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