Registration Dossier
Registration Dossier
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EC number: 220-358-3 | CAS number: 2736-23-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets national standard methods with acceptable restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,4-dichloro-5-sulphamoylbenzoic acid
- EC Number:
- 220-358-3
- EC Name:
- 2,4-dichloro-5-sulphamoylbenzoic acid
- Cas Number:
- 2736-23-4
- Molecular formula:
- C7H5Cl2NO4S
- IUPAC Name:
- 2,4-dichloro-5-sulphamoylbenzoic acid
- Test material form:
- solid - liquid: suspension
- Details on test material:
- M12325 was supplied by Hodogaya ChemicalCo., Ltd. (Tokyo, Japan).
State: water-soluble white powder
Melting point of 232 to 233.5°C.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: ddY
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Male weight at study initiation: 25 to 30 g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Remarks:
- Distilled water
- Doses:
- 3 g/kg
- No. of animals per sex per dose:
- 10 male
- Control animals:
- yes
- Details on study design:
- Mortality and clinical signs of abnormalities were observed for 7 days.
- Statistics:
- The significance of differences in survival rate was evaluated by the Fisher exact test.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Mortality:
- No mortality was observed.
- Clinical signs:
- No clinical signs were observed.
Applicant's summary and conclusion
- Conclusions:
- The substance was well tolerated in single intraperitoneal doses up to 3 g/kg in mice.
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