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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 30-09-1980 to 03-10-1980
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No data
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
CAS 2736-23-4
IUPAC Name:
CAS 2736-23-4
Constituent 2
Chemical structure
Reference substance name:
2,4-dichloro-5-sulphamoylbenzoic acid
EC Number:
220-358-3
EC Name:
2,4-dichloro-5-sulphamoylbenzoic acid
Cas Number:
2736-23-4
Molecular formula:
C7H5Cl2NO4S
IUPAC Name:
2,4-dichloro-5-sulfamoylbenzoic acid
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test animals

Species:
rabbit
Strain:
Himalayan
Details on test animals or test system and environmental conditions:
The experimental animals were albino Himalayan rabbits (strain: Hoe: HIMK (SPFWiga); own breeding) used in weight from 1.846 to 2.392 kg. The animals were kept in individual cages and were given the standard feed ERKA 8300 (feed mill Robert Koch oHG, Hamm / Westphalia.). Food and water were available ad libitum.

Test system

Type of coverage:
not specified
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Duration of treatment / exposure:
24h
Observation period:
24, 48 and 72h
Number of animals:
6

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Time point:
other: 48 and 72 h
Remarks on result:
other: Irritation index 1.4
Irritant / corrosive response data:
After application, the pasted substance was determined to be irritant with index 1,4., In addition, a rabbit skin after 48 and 72h was dry, rough, scaly and superficially cracked. Another rabbit skin was dry, rough and scaly.

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Based on the available results, the substance is thus regarded as slightly irritating to skin.

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