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Diss Factsheets
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EC number: 265-194-3 | CAS number: 64742-91-2 A complex combination of hydrocarbons obtained by the distillation of the products from a steam cracking process. It consists predominantly of unsaturated hydrocarbons having carbon numbers predominantly in the range of C7 through C16 and boiling in the range of approximately 90°C to 290°C (190°F to 554°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP near guideline study available as unpublished report (in German) but otherwise fully adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Toluene
- EC Number:
- 203-625-9
- EC Name:
- Toluene
- Cas Number:
- 108-88-3
- Molecular formula:
- C7H8
- IUPAC Name:
- toluene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Nominal: 7, 31.6, 52.2, 78.3, 104.4 mg/L
Analysed: 6.08, 20.00, 23.98, 38.87, 61.80 mg/L - No. of animals per sex per dose:
- 10
- Control animals:
- no
- Statistics:
- Probit analysis based on Finney (1971)
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 28.1 mg/L air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: 5/20 mortalities at 23.98 and 18/20 mortalities at 38.87 mg/L
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 25.7 mg/L air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: 3/10 mortalities at 23.98 and 10/10 at 38.87 mg/L
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 30 mg/L air (analytical)
- 95% CL:
- 25.5 - 36.8
- Exp. duration:
- 4 h
- Remarks on result:
- other: 2/10 mortalities at 23.98 and 8/10 mortalities at 38.87 mg/L
- Mortality:
- Mortality at 6.08, 20.00, 23.98, 38.87, 61.80 mg/L
Males: 0/10, 1/10, 3/10, 10/10, 10/10
Females: 0/10, 1/10, 2/10, 8/10, 10/10 - Clinical signs:
- other: Animals showed watery discharge from eyes and nose, unrest, increased respiration, rocking gait, narcosis, startling movements and hyperaemia of the ears and extremities. In the highest exposure group, salivation was observed. In the group exposed to 6.08
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Acute inhalation LC50 > 20 mg/L
- Executive summary:
Acute inhalation toxicity of toluene was investigated in 5 groups of 10 male and female rats exposed for 4 hours at concentrations of 6.08, 20.00, 23.98, 38.87 or 61.80 mg/L.
Adverse clinical signs and mortality were seen at concentrations of 20 mg/L and above. All surviving animals were normal by day 3. The LC50 exceeded 20 mg/L (25.7 mg/L in males, 30 mg/L in females).
Toluene does not warrant classification under GHS/CLP.
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