Registration Dossier

Administrative data

Endpoint:
repeated dose toxicity: other route
Remarks:
other: no data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
This is brief summary of a study.

Data source

Reference
Reference Type:
publication
Title:
Effects of subcutaneous injections of sodium tungstate on the rat.
Author:
Selle RM.
Year:
1942
Bibliographic source:
Federation Proceedings. Part I, Vol. 1, The American Society for Pharmacology and Experimental Therapeutics, Page 165.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The toxicity of repeat subcutanaeous dosing of sodium tungstate to rats was assessed.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Disodium wolframate
EC Number:
236-743-4
EC Name:
Disodium wolframate
Cas Number:
13472-45-2
Molecular formula:
Na2WO4
IUPAC Name:
disodium dioxotungstenbis(olate)
Details on test material:
- Name of test material (as cited in study report): sodium tungstate

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
not specified
Details on exposure:
- Male and female rats received daily doses of a 0.1 M aqueous solution of sodium tungstate at the rate of 0.05 cc per 10 grams of body weight.
Analytical verification of doses or concentrations:
no
Duration of treatment / exposure:
no data
Frequency of treatment:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
0.1 M aqueous solution of sodium tungstate
No. of animals per sex per dose:
no data
Control animals:
yes

Examinations

Statistics:
no data

Results and discussion

Results of examinations

Details on results:
- Treated male rats weighed 26% less than the controls.
- In males, the kidneys were 45% heavier than the controls.
- In females, the kidney weights were 42% heavier than the controls although the body weight was 11% less than the controls.
- A severe drop in rectal temperature was observed in treated animals, from 100.7 to 92.5 degrees F in 2 hours.
- After two hours the temperature slowly rose so that by 8 hours after the injection it had returned to 99.1 degrees F.
- There were no differences between the weights of the bodies, kidneys, and adrenal glands of treated male and female rats and the control animals.
- Most of the tungsten was eliminated in the urine within 12 hours.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion