Registration Dossier
Registration Dossier
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EC number: 605-717-8 | CAS number: 174333-80-3
Specific investigations: other studies
Administrative data
- Endpoint:
- endocrine system modulation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: according to P. Sohoni and J.P. Sumpter (1998)
- Principles of method if other than guideline:
- The yeast cells used in the yeast androgen screening (YAS) assay have been stably transformed with genes for the human androgen receptor and the ß-galactosidase reporter gene. Androgenic as well as antiandrogenic potentials of the test substances mediated by receptor binding or blocking can be determined using this assay, respectively.
- GLP compliance:
- no
- Type of method:
- in vitro
Test material
- Reference substance name:
- 2-[(hydroxyimino)methyl]-4-(2-methyloctyl)phenol; 2-[(hydroxyimino)methyl]-4-(3-methyloctyl)phenol; 2-[(hydroxyimino)methyl]-4-(4-methyloctyl)phenol; 2-[(hydroxyimino)methyl]-4-(nonan-2-yl)phenol
- EC Number:
- 605-717-8
- Cas Number:
- 174333-80-3
- Molecular formula:
- C16H25NO2
- IUPAC Name:
- 2-[(hydroxyimino)methyl]-4-(2-methyloctyl)phenol; 2-[(hydroxyimino)methyl]-4-(3-methyloctyl)phenol; 2-[(hydroxyimino)methyl]-4-(4-methyloctyl)phenol; 2-[(hydroxyimino)methyl]-4-(nonan-2-yl)phenol
- Details on test material:
- - Name of test material: C9Aldoxim
- Physical state: Liquid, greenyellow, clear
- Analytical purity: >90%
- Storage condition of test material: Room temperature
Constituent 1
Test animals
- Species:
- other: yeast
Administration / exposure
- Vehicle:
- DMSO
Results and discussion
- Details on results:
- In this study, the test substance C9 Aldoxim showed no androgenic activity in comparison to dihydrotestosterone.
In this study, the test substance C9 Aldoxim showed clear antiandrogenic activity from about 10-6 mol/L onward in comparison to hydroxyflutamide.
No cytotoxicity was observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
