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Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Guideline:
other: read across (grouping: skin irritation inclusion rules by BfR-ketones)
GLP compliance:
no
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Score:
1.73
Max. score:
8

See attached OECD Toolbox v2.0 study for skin irritation/corrosion.

Note that v3.1 gave identical results.

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Classification Xi;R38 (DSD) respectively Skin irritant cateory 2 with H315 (CLP)
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation
Remarks:
other: read across
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Guideline:
other: read across (grouping: skin irritation inclusion rules by BfR-ketones)
GLP compliance:
no
Irritation parameter:
other: Modified maximum average score
Basis:
mean
Score:
30.4
Max. score:
110

See attached OECD Toolbox v2.0 study for eye irritation/corrosion.

Note that v3.1 gave identical results.

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Classification Xi;R36 (DSD), respectively Eye irritant category 2 with H319
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Effects on skin irritation/corrosion: irritating

Effects on eye irritation: irritating

Justification for classification or non-classification

Based on the results found this substance must be classified as:

Skin irritant category 2 with H315 (causes skin irritation)

Eye irritant category 2 with H319 (causes serious eye irritation)

STOT SE category 3 for inhalation with H335 (may cause respiratory irritation)

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