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EC number: 204-111-7 | CAS number: 115-84-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 22 to 25 December 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline and GLP-compliant proprietary study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-Ethyl-2-butyl-1,3-propanediol
- IUPAC Name:
- 2-Ethyl-2-butyl-1,3-propanediol
- Reference substance name:
- 2-butyl-2-ethylpropanediol
- EC Number:
- 204-111-7
- EC Name:
- 2-butyl-2-ethylpropanediol
- Cas Number:
- 115-84-4
- Molecular formula:
- C9H20O2
- IUPAC Name:
- 2-butyl-2-ethylpropane-1,3-diol
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): Ethyl butyl propanediol
- Physical state: colourless crystalline powder
- Analytical purity: 98.2%
- Storage conditions: at room temperature
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Rabbits were supplied by Rosemead Rabbits, Waltham Abbey, Essex, England. They were 10 to 13 weeks old and in a weight range of 2.4 to 2.7 kg, prior to treatment on Day 1. The animal room temperature was maintained at 19°C with a relative humidity at 30-70%. Air exchange was maintained at 19 air changes/hour and lighting was controlled to give 12 hours of artificial light in each 24 hour period.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3
- Details on study design:
- The dermal test site was shaved 24 hours prior to application. The test material was moistened with distilled water. At completion of exposure, the bandages were removed and the sites were washed with water.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0.11
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: Very slight erythema only persisted in 1 animal on Day 2.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: Very slight oedema achieved on Day 1 only.
- Irritant / corrosive response data:
- Effects were transient and reversible.
- Other effects:
- None reported
Any other information on results incl. tables
The test material induced very slight erythema and oedema in all animals. One animal was observed with very slight erythema on Day 2. All reactions had resolved by Day 2 or 3.
Rabbit number |
E = Erythema O = Oedema |
Day |
|||
1* |
2 (24 h) |
3 (48 h) |
4 (72 h) |
||
1828F |
E |
1 |
0 |
0 |
0 |
O |
1 |
0 |
0 |
0 |
|
1829F |
E |
1 |
1 |
0 |
0 |
O |
1 |
0 |
0 |
0 |
|
1830F |
E |
1 |
0 |
0 |
0 |
O |
1 |
0 |
0 |
0 |
* Approximately 30 minutes after removal of the dressing
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- BEPD was found to be a transient skin irritant under the conditions of this study. Mean scores for the 24-72 hour assessments did not exceed EU classification thresholds.
- Executive summary:
0.5 g of the test material (moistened with distilled water) was applied for 4 hours under semi-occlusive conditions to the shorn dorsal skin of three New Zealand White Rabbits. Exposure to the test material was terminated by washing the skin with water. Local dermal irritation was assessed at 1, 24, 48 and 72 hours. Very slight erythema and oedema were observed at the 30 minute reading in all three animals. Very slight erythema only persisted in one animal on Day 2. All reactions had resolved by Day 2 or 3. BEPD was found to be only minimally irritant under the conditions of this study.
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