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EC number: 205-517-7 | CAS number: 141-98-0
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- JAN 2013 - MAR 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- Buffer pH 4,
Buffer pH 7,
Buffer pH 9, - Duration:
- 168 h
- pH:
- 4
- Initial conc. measured:
- > 0.09 - < 0.107 g/L
- Duration:
- 120 h
- pH:
- 7
- Initial conc. measured:
- > 0.1 - < 0.1 g/L
- Duration:
- 120 h
- pH:
- 9
- Initial conc. measured:
- > 0.096 - < 0.096 g/L
- Number of replicates:
- 2 replicates per pH value
- Positive controls:
- not specified
- Negative controls:
- not specified
- Transformation products:
- not specified
- % Recovery:
- > 99.5
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 168 h
- % Recovery:
- > 99.7 - < 103
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- > 108 - < 115
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 120 h
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Remarks on result:
- other: Estimated from results at 50 ºC
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Remarks on result:
- other: Estimated from results at 50 ºC
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Remarks on result:
- other: Estimated from results at 50 ºC
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test item was found not to hydrolyse at pH 4 - 7 - 9, half-life greater than 1 year at 25 ºC
- Executive summary:
Hydrolysis test was done according to OECD Guideline 111. The test item was found not to hydrolyse at pH 4 - 7 - 9, half-life greater than 1 year at 25 ºC
Reference
Description of key information
Hydrolysis test was done according to OECD Guideline 111. The test item was found not to hydrolyse at pH 4 - 7 - 9, half-life greater than 1 year at 25 ºC
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
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