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EC number: 279-815-0 | CAS number: 81782-77-6
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Key study: 48 h EC50 0.40 mg a.i./L, Daphnia magna, OECD 202, EPA OPPTS 850.1010, Broughter et al. 2013b
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.4 mg/L
Additional information
The acute toxicity of the test material to aquatic invertebrates was investigated in Daphnia magna in a GLP study which was conducted in accordance with standardised guidelines OECD 202 and EPA OPPTS 850:1010. During the study the Daphnia were exposed to the test material at nominal concentrations of 0, 0.043, 0.094, 0.21, 0.45 and 1.0 mg a.i./L under flow-through conditions for 48 hours. The mean measured concentrations of the test material were 0, 0.032, 0.060, 0.12, 0.31 and 0.71 mg a.i./L, representing 40 - 90 % of the nominal values. Daphnia in the negative and solvent control groups appeared normal throughout the test, with no immobility or signs of toxicity. Percent immobility at test termination in the 0.032, 0.060, 0.12, 0.31 and 0.71 mg a.i./L mean measured concentration treatment groups was 0, 0, 5, 20 and 100 %, respectively. Floating daphnids were observed in the 0.12, 0.31 and 0.71 mg a.i./L treatment groups at the initial observation approximately 4 hours after test initiation, and at the 24 hour observation interval in the 0.12 and 0.31 mg a.i./L treatment groups. All floating daphnids in the 0.12, 0.31 and 0.71 mg a.i./L treatment groups appeared normal after being gently submerged. Lethargy was also observed in the 0.12 and 0.31 a.i./L treatment groups at the final observation interval (48 hours). Under the conditions of the study the 48 hour EC50 of the test material based on mean measured test concentrations was determined to be 0.40 mg a.i./L with a 95% confidence interval of 0.31 to 0.71 mg a.i./L. The no-immobility concentration was 0.060 mg a.i./L and the No Observed Effect Concentration was 0.060 mg a.i./L.
The study was performed in line with GLP and accepted standardised guidelines with a high standard of reporting. The study was assigned a reliability score of 1 in accordance with the principles for assessing data quality as defined in Klimisch (1997).
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