17H-Dicyclopropa[6,7:15,16]cyclopenta[a]phenanthren-17-one, octadecahydro-3,5-dihydroxy-10,13-dimethyl-, (3S,5R,6R,7R,8R,9S,10R,13S,14S,15S,16S)-

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2001-04-10 to 2001-04-11

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2002

Report date:

2002

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

No version available

Deviations:

yes

Remarks:

Since the vapor pressure was expected to be very low, a mixture of substances was examined. If the vapor pressure of the mixture did not exceed a certain value, this would also be valid for every single substance.

GLP compliance:

yes

Type of method:

effusion method: vapour pressure balance

Test material

Test material information

Constituent 1

Reference substance name:

3 beta,5-Dihydroxy-6 beta,7 beta;15 beta,16 beta-dimethylene-5 beta-androstan-17-one

EC Number:

617-347-4

Cas Number:

82543-16-6

Molecular formula:

C21 H30 O3

IUPAC Name:

3 beta,5-Dihydroxy-6 beta,7 beta;15 beta,16 beta-dimethylene-5 beta-androstan-17-one

Test material form:

solid

Results and discussion

Vapour pressure

Key result

Temp.:

25 °C

Vapour pressure:

< 0.001 Pa

Applicant's summary and conclusion

Executive summary:

The vapor pressure of ZK 34517 was determined using a screening method based on the detection of the evaporation rate from a Knudsen cell of a vapor pressure balance at 25 °C. Since simplified experimental conditions are also acceptable within the scope of this project, ZK 34517 was mixed with four other compounds. From all five test substances low or very low vapor pressures, based on the study director’s experience, were expected. For this reason the experiments consisted in the measurement of the evaporation rate of the mixture from a Knudsen cell a 25 °C. Since the evaporation rate of the mixture was below the value derived from the lower limit of the vapor pressure range recommended for the use of a vapor pressure balance (1E-03 Pa, EC Testing Guideline A.4) it can be assumed that the vapor pressure of the mixture is lower than 1E-03 Pa. Considering this fact, the vapor pressure of the single compounds in the mixture has also to be lower than 1E-03 Pa. Therefore, the vapor pressure of ZK 34517 can be estimated to be at 25 °C: p25 < 1E-03 Pa.