Registration Dossier
Registration Dossier
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EC number: 218-059-8 | CAS number: 2044-64-6
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- a short-term toxicity study does not need to be conducted because exposure of humans via the dermal route in production and/or use is not likely as based on the provided thorough and rigorous exposure assessment
- Justification for type of information:
- In accordance with point 8.6.1, column 1 of Annex IX of Regulation (EC) No. 1907/2006, testing for this endpoint should be performed using an appropriate route of exposure. A 28 day oral study was submitted to fulfil the subacute toxicity endpoint. Exposure via the oral route is considered an appropriate route of exposure for the submitted substance, as it is known to be readily absorbed following oral administration. Further testing for this endpoint via the dermal route of exposure is considered less appropriate and is therefore omitted on this basis.
Data source
Materials and methods
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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