Registration Dossier
Registration Dossier
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EC number: 249-125-4 | CAS number: 28654-73-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (incomplete documentation, occlusive treatment)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- (occlusive treatment)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- [N,N,N',N',N'',N''-hexaethyl-29H,31H-phthalocyaninetrimethylaminato(2-)-N29,N30,N31,N32]copper
- EC Number:
- 249-125-4
- EC Name:
- [N,N,N',N',N'',N''-hexaethyl-29H,31H-phthalocyaninetrimethylaminato(2-)-N29,N30,N31,N32]copper
- Cas Number:
- 28654-73-1
- Molecular formula:
- C47 H49 Cu N11
- IUPAC Name:
- Copper,[N,N,N',N',N'',N''-hexaethyl-29H,31H-phthalocyanine-C,C,C-trimethanaminato(2-)-κN29,κN30,κN31,κN32]-
- Details on test material:
- - Physical state: solid
- Analytical purity: ca. 93%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Wiga
- Weight range at study initiation: 135 - 161 g (males); 116 - 119 g (females)
ENVIRONMENTAL CONDITIONS: not reported
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 50 cm²
- % coverage: > 10 %
- Site of exposure: right back
REMOVAL OF TEST SUBSTANCE
- Washing: with water containing mild detergent
TEST MATERIAL
- Amount applied: 2500 mg/kg bw (5 mL/kg bw)
- Concentration (if solution): 50 % (in water)
- For solids, paste formed: yes - Duration of exposure:
- 24 h
- Doses:
- 2500 mg/kg bw
- No. of animals per sex per dose:
- 5 rats
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: before application
- Frequency of observations: daily (on working day) day 1, 2, 5, 6, 7, 8, 9, 12, 13 and 14
- Necropsy of survivors performed: yes - Statistics:
- not performed
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality and no clinical signs were observed.
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: No local or systemic signs of toxicity were observed. Only substance residues (light-blue) on the skin were seen during the whole observation period.
- Gross pathology:
- No abnormalities were observed.
Applicant's summary and conclusion
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