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Administrative data

Endpoint:
auto-flammability
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
2014
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study is classified as reliable with restrictions because it is an acceptable and reliable study carried out by OECD ToolBox v.3.2.0. Meets generally accepted scientific principles, acceptable for assessment.

Data source

Reference
Reference Type:
other: software
Title:
QSAR ToolBox 3.2.0.103
Author:
OECD
Year:
2014
Bibliographic source:
http://www.oecd.org/env/ehs/risk-assessment/theoecdqsartoolbox.htm

Materials and methods

Principles of method if other than guideline:
Read-across from category members.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Prednisolone
EC Number:
200-021-7
EC Name:
Prednisolone
Cas Number:
50-24-8
IUPAC Name:
11,17,21-trihydroxypregna-1,4-diene-3,20-dione
Constituent 2
Reference substance name:
103335-54-2
EC Number:
600-423-6
Cas Number:
103335-54-2
IUPAC Name:
103335-54-2

Results and discussion

Auto-ignition temperature (liquids / gases)
Auto-ignition temperature:
372 °C
Atm. press.:
760 mm Hg
Remarks on result:
other: Stimated by OECD Toolbox
Relative self-ignition temperature (solids)
Relative self-ignition temperature:
372 °C
Remarks on result:
other: Stimated by OECD Toolbox
Remarks:
at atm. press. of 760.0 mm Hg

Any other information on results incl. tables

Autoflammability of the target chemical (372 °C) is predicted from category member using read-across from 2 nearest neighbours compared by prediction descriptors.

The target chemical FALLS within applicability domain.

Applicant's summary and conclusion

Conclusions:
Autoflammability has been estimated by read-across to be 372°C.