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EC number: 201-209-1 | CAS number: 79-46-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- hepatotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No data on GLP, sufficient data is available for interpretation of results.
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparison of the Hepatotoxicity in Mice and the Mutagenicity of Three Nitroalkanes
- Author:
- Dayal, R., Gescher, A., Harpur, E.S., Pratt, I., Chipman, J.K.
- Year:
- 1 989
- Bibliographic source:
- Fundamental and Applied Toxicology, 13:341-348
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- 2-nitropropane
- EC Number:
- 201-209-1
- EC Name:
- 2-nitropropane
- Cas Number:
- 79-46-9
- Molecular formula:
- C3H7NO2
- IUPAC Name:
- 2-nitropropane
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Balb/c
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: DMSO in phosphate buffer solution
- Details on exposure:
- Mice were injected with the test cimpounds via the IP route in a volume of 0.2 mL.
- Duration of treatment / exposure:
- single injection
- Frequency of treatment:
- once
- Post exposure period:
- 96 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 4.5, 6.7, 9.0 mmol/kg
Basis:
nominal conc.
- No. of animals per sex per dose:
- 3-5/sex/dose
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Nitroalkanes were dissolved in DMSO and then diluted with phosphate buffer to a pH~7.8. BALB/c mice were obtained from a commercial supplier and fed a commercial breeding diet. They were treated in dose groups of 3-5.
Mice were injected with the test cimpounds via the IP route in a volume of 0.2 mL. Mice were sacrificed at 24, 48, or 96 hours post-dosing, and plasma was assayed for measurements of sorbitol dehydrogenase (SDH), alanine aminotransferase (ALT), and aspartate aminotransferase (AST). For histopathological investigation, livers were fixed, hydrated, and embedded. Sections from at least 3 lobes were cut and stained, and sections were evaluated blindly.
Examinations
- Examinations:
- Mice were sacrificed at 24, 48, or 96 hours post-dosing, and plasma was assayed for measurements of sorbitol dehydrogenase (SDH), alanine aminotransferase (ALT), and aspartate aminotransferase (AST). For histopathological investigation, livers were fixed, hydrated, and embedded. Sections from at least 3 lobes were cut and stained, and sections were evaluated blindly.
Results and discussion
- Details on results:
- A consistent finding was the absence of any effect in male mice 24 hours after dosing up to 9 mmol. Mean enzyme levels in plasma were elevated at 48 and 96 hours. Individual mice showed a striking variability in their succeptibility to the hepatotoxic effect of 2-NP, and there was a sex-dependent difference (females with larger increases in enzyme activity). The most severely affected livers showed an extensive hemorrhagic necrosis with apoptosis and disruption of the normal parenchyma. Mild proliferation of ductal-type cells in periportal areas was also noted. Less affected livers had single-cell necrosis, predominantly in a periportal location.
Applicant's summary and conclusion
- Conclusions:
- Mean enzyme levels in plasma were elevated at 48 and 96 hours. Individual mice showed a striking variability in their succeptibility to the hepatotoxic effect of 2-NP, and there was a sex-dependent difference (females with larger increases in enzyme activity).
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