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Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: special investigation

Data source

Reference
Reference Type:
publication
Title:
Inhibition of carcinogen-induced neoplasia by sodium cyanate, tert-butylisocyanate, and benzyl isothiocyanate administered subsequent to carcinogen exposure
Author:
Wattenberg LW
Year:
1981
Bibliographic source:
Cancer Res 41, 2991-2994

Materials and methods

Type of study / information:
inhibition of carcinogen-induced neoplasia by tert-butylisocyanate
Principles of method if other than guideline:
The effects of sodium cyanate, tert-butyl isocyanate, and benzyl isothiocyanate on carcinogen-induced neoplasia were studied in experiments in which the test compound was fed starting·1 week following completion of carcinogen administrations.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
tert-butyl isocyanate
EC Number:
216-544-9
EC Name:
tert-butyl isocyanate
Cas Number:
1609-86-5
Molecular formula:
C5H9NO
IUPAC Name:
tert-butyl isocyanate
Constituent 2
Reference substance name:
tert-butylisocyanate
IUPAC Name:
tert-butylisocyanate
Details on test material:
rwer-butylisocyanate was obtained from Aldrich

Results and discussion

Any other information on results incl. tables

Under these conditions, all three test compounds including tert-butylisocyanate exerted an inhibitory effect on the occurrence of 7,12-dimethylbenz(a)anthracene-induced neoplasia of the breast of Sprague-Dawley rats.

Applicant's summary and conclusion

Executive summary:

The effects of sodium cyanate, tert-butyl isocyanate, and benzyl isothiocyanate on carcinogen-induced neoplasia were studied in experiments in which the test compound was fed starting·1 week following completion of carcinogen administrations.

Under these conditions, all three test compounds including tert-butylisocyanate exerted an inhibitory effect on the occurrence of 7,12-dimethylbenz(a)anthracene-induced neoplasia of the breast of Sprague-Dawley rats.