Registration Dossier
Registration Dossier
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EC number: 216-544-9 | CAS number: 1609-86-5
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: special investigation
Data source
Reference
- Reference Type:
- publication
- Title:
- Inhibition of carcinogen-induced neoplasia by sodium cyanate, tert-butylisocyanate, and benzyl isothiocyanate administered subsequent to carcinogen exposure
- Author:
- Wattenberg LW
- Year:
- 1 981
- Bibliographic source:
- Cancer Res 41, 2991-2994
Materials and methods
- Type of study / information:
- inhibition of carcinogen-induced neoplasia by tert-butylisocyanate
- Principles of method if other than guideline:
- The effects of sodium cyanate, tert-butyl isocyanate, and benzyl isothiocyanate on carcinogen-induced neoplasia were studied in experiments in which the test compound was fed starting·1 week following completion of carcinogen administrations.
- GLP compliance:
- no
Test material
- Reference substance name:
- tert-butyl isocyanate
- EC Number:
- 216-544-9
- EC Name:
- tert-butyl isocyanate
- Cas Number:
- 1609-86-5
- Molecular formula:
- C5H9NO
- IUPAC Name:
- 2-isocyanato-2-methylpropane
- Reference substance name:
- tert-butylisocyanate
- IUPAC Name:
- tert-butylisocyanate
- Details on test material:
- rwer-butylisocyanate was obtained from Aldrich
Constituent 1
Constituent 2
Results and discussion
Any other information on results incl. tables
Under these conditions, all three test compounds including tert-butylisocyanate exerted an inhibitory effect on the occurrence of 7,12-dimethylbenz(a)anthracene-induced neoplasia of the breast of Sprague-Dawley rats.
Applicant's summary and conclusion
- Executive summary:
The effects of sodium cyanate, tert-butyl isocyanate, and benzyl isothiocyanate on carcinogen-induced neoplasia were studied in experiments in which the test compound was fed starting·1 week following completion of carcinogen administrations.
Under these conditions, all three test compounds including tert-butylisocyanate exerted an inhibitory effect on the occurrence of 7,12-dimethylbenz(a)anthracene-induced neoplasia of the breast of Sprague-Dawley rats.
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