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Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
other information
Study period:
2000-12-11 to 2000-12-14
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002
Report date:
2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
5-Hydroxy-15 beta,16 beta-methylene-3 beta-pivaloyloxy-5 beta-androst-6-en-17-one
EC Number:
617-345-3
Cas Number:
82543-14-4
Molecular formula:
C25 H36 O4
IUPAC Name:
5-Hydroxy-15 beta,16 beta-methylene-3 beta-pivaloyloxy-5 beta-androst-6-en-17-one

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
3.9
Temp.:
25 °C
pH:
7

Applicant's summary and conclusion

Executive summary:

The n-octanol/water partition coefficient of ZK 90504 was determined according to EU Testing Guideline A.8 (HPLC method based on OECD guideline no. 117) to be

log Pow = 3.90 (95 % confidence limits 3.70 - 4.11)

which indicates high lipophilicity. The method is based on the correlation of the reversed phase retention data of the test compound with those of reference compounds with known log Pow values.

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