Registration Dossier

Administrative data

Endpoint:
fertility, other
Remarks:
based on test type (migrated information)
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original data not available

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978

Materials and methods

Principles of method if other than guideline:
Male Wistar rats were exposed to 0.018 mg/l (2.78 ppm) for 5 days. Food consumption, body weights, pregnancy rate, mean number of total and dead implants and preimplantation were observed.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3,4-trichlorobut-1-ene
EC Number:
219-397-9
EC Name:
2,3,4-trichlorobut-1-ene
Cas Number:
2431-50-7
Molecular formula:
C4H5Cl3
IUPAC Name:
2,3,4-trichlorobut-1-ene

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
inhalation
Duration of treatment / exposure:
Exposure period: 5d
Frequency of treatment:
6h/d
Doses / concentrations
Remarks:
Doses / Concentrations:
0.018 mg/l (2.78 ppm)
Basis:

Control animals:
yes

Results and discussion

Overall reproductive toxicity

Reproductive effects observed:
not specified

Any other information on results incl. tables

Freetext:
decreased food consumption and body weights during
exposure; pregnancy rate, mean number of total and dead
implants and preimplantation were not adversely affected

Applicant's summary and conclusion