Registration Dossier

Administrative data

Endpoint:
developmental toxicity
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original data not available

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1978
Reference Type:
secondary source
Title:
No information
Author:
!SIDSP*
Year:
1993
Bibliographic source:
OECD/SIDS. Screening Information Data Set (SIDS) of OECD High Production Volume Chemicals Programme, 19, (1993)

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 414 (Prenatal Developmental Toxicity Study)
Principles of method if other than guideline:
Developmental toxicity and teratogenicity were analyzed
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3,4-trichlorobut-1-ene
EC Number:
219-397-9
EC Name:
2,3,4-trichlorobut-1-ene
Cas Number:
2431-50-7
Molecular formula:
C4H5Cl3
IUPAC Name:
2,3,4-trichlorobut-1-ene
Details on test material:
- Name of test material (as cited in study report): 1-Butene, 2,3,4-trichloro

Test animals

Species:
rat
Strain:
Wistar

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure (if applicable):
not specified
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Details on mating procedure:
no data
Duration of treatment / exposure:
6th to 16th day of gestation
Frequency of treatment:
6h/d
Duration of test:
10 d
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 0.0007, 0.003, 0.017 mg/L (0, 0.1, 0.5, 2.5 ppm)
Basis:

No. of animals per sex per dose:
no data
Control animals:
yes
Details on study design:
Post observation period: until 21st day of gestation

Results and discussion

Results: maternal animals

Maternal developmental toxicity

Details on maternal toxic effects:
Maternal toxic effects:yes

Details on maternal toxic effects:
At 2.5 ppm: decreased food consumption and bodyweights

Effect levels (maternal animals)

open allclose all
Dose descriptor:
NOAEC
Effect level:
0.003 other: mg/L
Basis for effect level:
other: maternal toxicity
Dose descriptor:
LOAEC
Effect level:
0.017 other: mg/L
Basis for effect level:
other: maternal toxicity

Results (fetuses)

Details on embryotoxic / teratogenic effects:
Embryotoxic / teratogenic effects:no data

Details on embryotoxic / teratogenic effects:
At 2.5 ppm: decreased foetal weight, no teratogenicity

Effect levels (fetuses)

open allclose all
Dose descriptor:
NOAEC
Effect level:
0.003 other: mg/L
Basis for effect level:
other: teratogenicity
Dose descriptor:
LOAEC
Effect level:
0.017 other: mg/L
Basis for effect level:
other: fetotoxicity

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Any other information on results incl. tables

Freetext:
NOEL for maternal animals: 0.5 ppm
NOEL for offspring: 0.5 ppm
Maternal general toxicity: decreased food consumption and
bodyweights in the 2.5 ppm-group
Pregnancy and litter data: decreased foetal weight in the
2.5 ppm-group, no teratogenicity

Applicant's summary and conclusion