Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Description of key information
In a reproductive/developmental toxicity screening study, a test substance dosing of 300/250 mg/kg/day resulted in the death of two females following the first dose at 300 mg/kg/day and one female at gestation day 20 following reduction of the dose to 250 mg/kg/day starting on study day 1. Body weight and food consumption were reduced primarily during the first week of the pre-mating period in the 300/250 mg/kg/day group. A single animal in the 300/250 mg/kg/day dose group had total litter loss; no effects on live litter size or postnatal survival were observed in the litters of the other dams in this group. No test article-related adverse effects were observed at 50 and 150 mg/kg/day. The NOAEL for this OECD 421 study was considered to be 150 mg/kg/day.

Justification for classification or non-classification

According to EU classification criteria, classification for toxicity to reproduction is not required.

Additional information