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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report date:
1989

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide
EC Number:
278-355-8
EC Name:
Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide
Cas Number:
75980-60-8
Molecular formula:
C22H21O2P
IUPAC Name:
(mesitylcarbonyl)(diphenyl)phosphine oxide
Details on test material:
- Name of test material (as cited in study report): Lucirin LR 8728 [Chemical name: diphenyl (2,4,6-trimethylbenzoyl) phosphineoxide]
- Analytical purity: not reported
- Physical state: pale yellow-coloured powder
- Lot/batch No.: 010213
- Storage condition of test material: stored in brown glass screw-top jars at approximately 4°C in the refrigerator

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: CFY strain rats supplied by Bantin & Kingman Ltd, Grimston, Aldborough, Hull, UK
- Age at study initiation: approximately five to eight weeks old
- Weight at study initiation: mean weights: males weighed 126 - 150g, and the females 120 - 142g,
- Fasting period before study: overnight immediately before dosing and for approximately two hours after dosing
- Housing: 5 by sex in solid-floor polypropylene cages with sawdust bedding; the animals were given a unique number within the study by ear punching and a number written on a cage card
- Diet: Rat and Mouse Expanded Diet No 1, Special Diet Services Ltd, Witham, Essex, UK; ad libitum
- Water: drinking water, ad libitum
- Acclimation period: at least 5 days


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 21
- Humidity (%): 46 - 60
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
arachis oil
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 50, 100, 300 and 500 mg/ml
- Amount of vehicle (if gavage): 10 ml
- Justification for choice of vehicle: test substance administered as suspension
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were observed 1 and 4 hours after dosing and subsequently once daily for 14 days. Deaths and evidence of overt toxicity were recorded at each observation
- Necropsy of survivors performed: yes, all animals were subjected to gross necropsy examination for any macroscopic abnormalities. No tissues were retained.
- Other examinations performed: individual body weights were recorded on the day of treatment (day 0) and on days 7 and 14

Results and discussion

Preliminary study:
Because no deaths occurred in the range-finding study, LD50 of the test substance was considered to be greater than 5000 mg/kg bw and the highest dose level was therefore used for the main study.
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Remarks on result:
other: no mortality occured
Mortality:
no mortality
Clinical signs:
other: - Hunched posture, lethargy and piloerection were noted in all animals one and four hours after dosing. - Decreased respiratory rate was also noted in all animals one hour after dosing. - All animals appeared normal one day after treatment.
Gross pathology:
no abnormalities were noted at necropsy of animals (killed at the end of the study).

Any other information on results incl. tables

Mean body weights (g):

Males:

Time  5000 mg/kg bw group
 Day 0  137.6±9.6
 Day 7  170.8±11.6
 Day 14  216.2±12.5

Females:

Time  5000 mg/kg bw group
 Day 0  128.8±8.4
 Day 7  152.6±7.7
 Day 14  180.6±12.0

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met