Registration Dossier

Administrative data

Description of key information

Lead salts are not expected to be skin irritants based on animal data on lead chloride.  Lead salts are expected to be severe eye irritants based on data from in vitro studies.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Effects on eye irritation: highly irritating

Justification for classification or non-classification

Lead acetate should be classified as a severe irritant based on the in-vitro eye irritation data (mean opacity score of 76.6) and should be classified as a category 1 eye irritant under CLP.

No skin irritation was observed in rabbits exposed for 24 hours to a similar water soluble lead salt. Lead acetate is expced to respond in a similar manner. No classification for skin irritation is necessary.