Registration Dossier

Toxicological information

Endpoint summary

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Administrative data

Description of key information

In vivo skin sensitisation data are available for various lead substances. There is no indication that lead substances cause skin sensitisation. There is also a publication available with lead di(acetate) with experimental results on an LLNA study (OECD 429) which did not indicate a skin sensitisation potential.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)

Justification for classification or non-classification

Based on a publication available for lead di(acetate), there is no indication that lead di(acetate) possess skin sensitisation in a local lymph node assay performed in 1999. Hence, there is no need to classify lead di(acetate) as skin sensitiser in accordance with regulation (EC) No 1907/2006 (REACH) Annex VII section 8.3.