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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
genetic toxicity in vitro, other
Remarks:
yeast gene conversion and reverse mutation assay
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1985

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A gene conversion and reverse mutation assay was performed in a diploid D7 strain of Saccharomyces cerevisiae after treatment with lead nitrate at concentrations of 0, 0.007, 0.015, 0.03, and 0.06 mg/ml.
GLP compliance:
not specified
Type of assay:
other: yeast gene conversion and reverse mutation assay

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Test results
Species / strain:
Saccharomyces cerevisiae
Metabolic activation:
without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
cytotoxicity
Vehicle controls validity:
not specified
Untreated negative controls validity:
not examined
Positive controls validity:
not examined
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Any other information on results incl. tables

Lead nitrate did not induce gene conversion or reverse mutation in yeast at any concentration tested.

Applicant's summary and conclusion

Conclusions:
Interpretation of results: negative
Executive summary:

A gene conversion and reverse mutation assay was performed in a diploid D7 strain of Saccharomyces cerevisiae after treatment with lead nitrate at concentrations of 0, 0.007, 0.015, 0.03, and 0.06 mg/ml. Lead nitrate did not induce gene conversion or reverse mutation in yeast at any concentration tested.