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EC number: 205-440-9 | CAS number: 140-90-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- Assessment based on chemistry and data derived from key metabolites
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Assessment of existing data on the substance and key metabolites formed by hydrolysis.
Cross-reference
- Reason / purpose for cross-reference:
- assessment report
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 022
- Report date:
- 2022
Materials and methods
- Objective of study:
- absorption
- distribution
- excretion
- metabolism
- other: Hydrolysis
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Assessment of gastric hydrolysis and potential adsorption, distribution and excretion of hydrolysis products based on published data for the metabolites
The approach taken is to consider the chemical structure and class of this substance and to look at the existing data set for the substance itself and for the well-defined hydrolysis products.
Searches for similar substances have been performed using commercial directories and the ECHA web-site to help provide a weight of evidence for metabolic processes of the parent substance and the hydrolysis products - GLP compliance:
- no
Test material
- Reference substance name:
- Sodium O-ethyl dithiocarbonate
- EC Number:
- 205-440-9
- EC Name:
- Sodium O-ethyl dithiocarbonate
- Cas Number:
- 140-90-9
- Molecular formula:
- C3H6OS2.Na
- IUPAC Name:
- sodium (ethoxymethanethioyl)sulfanide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- 92.1 wt.% of sodium ethyl xanthate (CAS# 140-90-9)
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: Non-animal assessment
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- The substance is unlikely to be directly absorbed in view of the extremely rapid hydrolysis to carbon disulphide and corresponding aliphatic alcohol
- Type:
- absorption
- Results:
- Carbon disulphide and low molecular weight aliphatic alcohols are readily absorbed by inhalation.
- Type:
- distribution
- Results:
- Impart to spleen and liver, mainly through blood chemistry changes, demonstrate distribution of the hydrolysis products and their metabolites
- Type:
- metabolism
- Results:
- Low molecular weight aliphatic alcohols metabolise to carbon dioxide and water and used in metabolic processes associated with energy.
- Type:
- excretion
- Results:
- No evidence of significant excretion of parent substance or hydrolysis products through urine
- Type:
- clearance
- Results:
- Low molecular weight aliphatic alcohols can be excreted through air
Carbon disulphide shown to be excreted through air exchange
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- • The substance is unlikely to be absorbed orally in view of the extremely rapid hydrolysis to carbon disulphide and corresponding aliphatic alcohol
• The substance is considered highly irritating to skin and there is no evidence of dermal absorption, although in the presence of moisture, hydrolysis is likely. It is possible that the reported local dermal reaction is directly linked to reactivity on the skin surface.
• Inhalation exposure to the parent substance is not considered significant, although exposure to the hydrolysis products cannot be ignored. - Details on distribution in tissues:
- • The metabolites are considered to be readily transported and metabolised further.
• Impact on organs including spleen and liver are consistent with carbon disulphide and alcohols.
Transfer into organs
- Test no.:
- #1
- Transfer type:
- blood/placenta barrier
- Remarks:
- Research into carbon disulphide demonstrates transfer across the placenta following inhalation exposure.
- Observation:
- slight transfer
- Remarks:
- Not quantified
- Details on excretion:
- No evidence of excretion of the parent substance or immediate hydrolysis products. Kidneys and urine appear not to be affected in any studies performed on the parent or hydrolysis products.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Remarks:
- Research into thiocarbamates found radiolabelled material was found to be excreted in urine in the form of complex sulphur-containing thiocarbonates Carbon disulphide found in urine and exhaled air in animal and humans following exposure to ethyl xanthate
- Details on metabolites:
- Low molecular weight aliphatic alcohols metabolise to carbon dioxide and water and used in metabolic processes associated with energy.
Enzymatic activity
- Enzymatic activity measured:
- Not specified
Applicant's summary and conclusion
- Conclusions:
- Non accumulative
- Executive summary:
From evidence derived from direct testing and from information obtained on the hydrolysis products, it can be concluded that:
- The substance is unlikely to be absorbed orally in view of the extremely rapid hydrolysis to carbon disulphide and corresponding aliphatic alcohol
- The substance is considered highly irritating to skin and there is no evidence of dermal absorption, although in the presence of moisture, hydrolysis is likely. It is possible that the reported local dermal reaction is directly linked to reactivity on the skin surface.
- A human study shows that CS2 is absorbed through the skin from aqueous solutions.
- Inhalation exposure to the parent substance is not considered significant, although exposure to the hydrolysis products cannot be ignored.
- The metabolites are considered to be readily transported and metabolised further.
- Impact on organs including spleen and liver are consistent with carbon disulphide and alcohols.
- No evidence of excretion of the parent substance or immediate hydrolysis products. Kidneys and urine appear not to be affected in any studies performed on the parent or hydrolysis products.
- CS2 is eliminated via exhaled air. After termination of exposure, the elimination of unaltered CS2 via the exhaled air amounts roughly to 5 -50% of the absorbed amount.
- Unaltered CS2 is hardly excreted via the kidneys: less than 1%
- Radiolabelled material was found to be excreted in urine in the form of complex sulphur-containing thiocarbonates suggesting incorporation of carbon disulphide into other substances
- Low molecular weight aliphatic alcohols can be excreted through air, but typically metabolise to carbon dioxide and water and used in metabolic processes associated with energy.
- The substance and the hydrolysis products and biological metabolites are not considered accumulative
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