Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-440-9 | CAS number: 140-90-9
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Guideline:
- other: no data
Test material
- Reference substance name:
- Sodium O-ethyl dithiocarbonate
- EC Number:
- 205-440-9
- EC Name:
- Sodium O-ethyl dithiocarbonate
- Cas Number:
- 140-90-9
- Molecular formula:
- C3H6OS2.Na
- IUPAC Name:
- sodium (ethoxymethanethioyl)sulfanide
Constituent 1
Results and discussion
Any other information on results incl. tables
The expired CS2in the exhaled air was monitored in the study of the metabolism of xanthates with humans and guinea pigs. After injection of 50 or 100mg/kg of sodium ethyl xanthate in guinea pigs up to 7% was expired as CS2during 8 hours. The rate of elimination was dose-related, however the total percentage recovered was independent of dose after administration of sodium or
potassium xanthate. Co injection of ethyl alcohol with sodium ethyl xanthate increased rate of CS2elimination and greater total recovery.
Study of CS2elimination in breath after oral intake in human volunteers of 150 and 250 mg of sodium ethyl xanthate showed a maximum rate 13-57 µm/m3/h between 1-2h, complete elimination by 6h
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
- Executive summary:
The expired CS2in the exhaled air was monitored in the study of the metabolism of xanthates with humans and guinea pigs. After injection of 50 or 100mg/kg of sodium ethyl xanthate in guinea pigs up to 7% was expired as CS2during 8 hours. The rate of elimination was dose-related, however the total percentage recovered was independent of dose after administration of sodium or
potassium xanthate. Co injection of ethyl alcohol with sodium ethyl xanthate increased rate of CS2elimination and greater total recovery.
Study of CS2elimination in breath after oral intake in human volunteers of 150 and 250 mg of sodium ethyl xanthate showed a maximum rate 13-57 µm/m3/h between 1-2h, complete elimination by 6h
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
