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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1951
Reference Type:
publication
Title:
Sodium ethyl xanthate. Priority existing chemical no. 5. NICNAS
Author:
Australian Government Publishing Service
Year:
1995
Bibliographic source:
Australian Government Publishing Service

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
GLP compliance:
not specified
Remarks:
This study predates the requirements for good laboratory practice, however the study was considered adequate for this assessment

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: 10% water solution of sodium ethyl xanthate (CAS# 140-90-9)

Test animals

Species:
mouse
Strain:
other: albino
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
730 mg/kg bw
Clinical signs:
The target organs for oral toxicity of SEX were the central nervous system, liver and spleen. The majority of death occurred on the first day, and the animals that survived appeared normal within two days
Gross pathology:
Depression followed by hyperexcitability, tremors, paralysis exophtaalmia and clonic followed by tonic convulsions.Pinkness of feet and nose, preening and salivation. Consolidated lungs, pale granular livers, unusually small spleens and atonic intestine. Surviving animals showed no abnormalities

Applicant's summary and conclusion