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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The study was considered not reliable since the documentation of the study was insufficient for assessment. Especially, no details on the test substance composition was provided.

Data source

Reference
Reference Type:
secondary source
Title:
Sodium Ethyl Xanthate - Priority Exiting Chemical No. 5
Author:
National Industrial Chemicals Notification and Assessment Scheme (NICNAS)
Year:
1995
Bibliographic source:
Australian Government Publishing Service Canberra

Materials and methods

Principles of method if other than guideline:
Sodium ethyl xanthate was administered by occlusive application to the shaved abdomen of the rabbits either as 1 g/kg bw of the 100% dry material in a paste formed with water. The animals were observed for 12 days.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
semi-solid (amorphous): gel
Remarks:
migrated information: paste

Test animals

Species:
rabbit

Administration / exposure

Type of coverage:
occlusive
Duration of exposure:
18 hrs
Doses:
1 000 mg/kg bw
No. of animals per sex per dose:
Three rabbits

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
< 1 000 mg/kg bw
Based on:
test mat.
Clinical signs:
Surviving animal had moderate irritation with oedema and pigmentation of the skin.
Gross pathology:
Moderate amount of peritoneal fluid, visceral organs were normal.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Rabbit were exposed to sodium ethyl xanthate for 18 hours. The LD50 value was concluded to be < 1 000 mg/kg bw.
Executive summary:

The study was considered not reliable since the documentation of the study was insufficient for assessment. Especially, no details on the test substance was provided. Thus, this study is used as a weight of evidence in the hazard assessment.