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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
30 days
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data on related xanthate provided as supporting information

Data source

Reference
Reference Type:
review article or handbook
Title:
Full Public Report Sodium Ethyl Xanthate Priority Existing Chemical No. 5
Author:
Australian Government Publishing Service Canberra
Year:
1995
Bibliographic source:
Australian Government Publishing Service Canberra

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Reference substance name:
Potassium O-pentyl dithiocarbonate
EC Number:
220-329-5
EC Name:
Potassium O-pentyl dithiocarbonate
Cas Number:
2720-73-2
IUPAC Name:
potassium O-pentyl dithiocarbonate
Constituent 2
Reference substance name:
Potassium amyl xanthate
IUPAC Name:
Potassium amyl xanthate
Test material form:
aerosol dispenser: not specified
Remarks:
migrated information: aerosol

Test animals

Species:
dog
Strain:
Beagle
Sex:
male

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Vehicle:
air
Analytical verification of doses or concentrations:
yes
Duration of treatment / exposure:
30-day
Frequency of treatment:
6 hrs daily, 5 days a week for a total of 20 exposures in 1 month
Doses / concentrationsopen allclose all
Dose / conc.:
100 mg/m³ air (nominal)
Dose / conc.:
800 mg/m³ air (nominal)
No. of animals per sex per dose:
2
Control animals:
yes

Examinations

Observations and examinations performed and frequency:
Daily

Results and discussion

Results of examinations

Clinical biochemistry findings:
no effects observed
Urinalysis findings:
no effects observed

Effect levels

Dose descriptor:
LOEC
Effect level:
100 mg/m³ air (nominal)
Based on:
test mat.
Sex:
male
Basis for effect level:
other: Hepatotoxic effects

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
The results of this study indicate that potassium amyl xanthate has an adverse effect on the the liver in dogs. There were no treatment-related changes in the haematological or urinalysis values in any of the animals.