Registration Dossier
Registration Dossier
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EC number: 205-440-9 | CAS number: 140-90-9
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Remarks:
- Inhalation, repeated exposure
- Adequacy of study:
- key study
- Study period:
- Up to 75 day exposure
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- In-vivo test using inhalation exposure of sodium ethyl xanthate
Secondary source is from Australian Government review
Primary source referenced
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 483 (Mammalian Spermatogonial Chromosome Aberration Test)
- Principles of method if other than guideline:
- Exposure was by inhalation over different periods up to 75 days
Precise methods not specified in secondary source - GLP compliance:
- not specified
- Type of assay:
- mammalian bone marrow chromosome aberration test
Test material
- Reference substance name:
- Sodium O-ethyl dithiocarbonate
- EC Number:
- 205-440-9
- EC Name:
- Sodium O-ethyl dithiocarbonate
- Cas Number:
- 140-90-9
- Molecular formula:
- C3H6OS2.Na
- IUPAC Name:
- sodium (ethoxymethanethioyl)sulfanide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: inhalation and oral
- Details on exposure:
- By inhalation at two sub-lethal concentrations over sub-chronic period
Treatment at 13.64 and 1.74 mg/m3 - Duration of treatment / exposure:
- For 1, 15, 45 or 75 days
- No. of animals per sex per dose:
- Not specified
Examinations
- Tissues and cell types examined:
- Bone marrow
- Details of tissue and slide preparation:
- Not specified
Results and discussion
Test results
- Sex:
- not specified
- Genotoxicity:
- ambiguous
- Toxicity:
- no effects
Any other information on results incl. tables
13.64 mg/m3 concentration increase the number of chromosomal disorders in bone marrow cells.
1.74 mg/m3 concentration had no mutagenic effect.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results : ambiguous
Low level of changes.
This s consistent with results seen with carbon disulphide
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