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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian germ cell study: cytogenicity / chromosome aberration
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Remarks:
Inhalation, repeated exposure
Adequacy of study:
key study
Study period:
Up to 75 day exposure
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
In-vivo test using inhalation exposure of sodium ethyl xanthate
Secondary source is from Australian Government review
Primary source referenced

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1979

Materials and methods

Test guideline
Guideline:
OECD Guideline 483 (Mammalian Spermatogonial Chromosome Aberration Test)
Principles of method if other than guideline:
Exposure was by inhalation over different periods up to 75 days
Precise methods not specified in secondary source
GLP compliance:
not specified
Type of assay:
mammalian bone marrow chromosome aberration test

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium O-ethyl dithiocarbonate
EC Number:
205-440-9
EC Name:
Sodium O-ethyl dithiocarbonate
Cas Number:
140-90-9
Molecular formula:
C3H6OS2.Na
IUPAC Name:
sodium (ethoxymethanethioyl)sulfanide

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: inhalation and oral
Details on exposure:
By inhalation at two sub-lethal concentrations over sub-chronic period
Treatment at 13.64 and 1.74 mg/m3
Duration of treatment / exposure:
For 1, 15, 45 or 75 days
No. of animals per sex per dose:
Not specified

Examinations

Tissues and cell types examined:
Bone marrow
Details of tissue and slide preparation:
Not specified

Results and discussion

Test results
Sex:
not specified
Genotoxicity:
ambiguous
Toxicity:
no effects

Any other information on results incl. tables

13.64 mg/mconcentration increase the number of chromosomal disorders in bone marrow cells.


1.74 mg/mconcentration had no mutagenic effect.

Applicant's summary and conclusion

Conclusions:
Interpretation of results : ambiguous
Low level of changes.
This s consistent with results seen with carbon disulphide