Registration Dossier

Toxicological information

Developmental toxicity / teratogenicity

Currently viewing:

Administrative data

Endpoint:
developmental toxicity
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
secondary source
Title:
Toxicological Profile for Carbon Disulfide ,
Author:
U.S. Department of Health and Human Services
Year:
1996
Bibliographic source:
U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry

Materials and methods

GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
mouse

Administration / exposure

Route of administration:
inhalation

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

Dose descriptor:
other:
Basis for effect level:
other: effect type not specified

Results (fetuses)

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Any other information on results incl. tables

Carbon disulfide and its metabolite pass the placenta at all stages of gestation and localize in brain blood liver and eye. Carbon disulfide or its metabolites may effects directly on the embryo.

Applicant's summary and conclusion